Our Research

Pioneering Leadership in Computational Biomedicine and Data Analytics

Much of the work at RRI involves the development of advanced mathematical models aimed at improving the care of dialysis patients and creating value for FMC. Mathematicians at RRI, in collaboration with FMC's Global Research and Development (GRD) division, have spearheaded the concept of virtual clinical trials (VCTs).

Treatment algorithms are developed and tested in large-scale VCTs using mathematical simulations of patients' physiology. In collaboration with the FMC Global Medical Office, VCT-derived algorithms have been implemented at Fresenius Kidney Care (FKC) clinics throughout North America, potentially benefiting over 160,000 FKC patients.

The computational biomedicine group works with other branches of RRI, including the clinical and laboratory research groups, data analytics team, and FMC GRD. A substantial proportion of the work undertaken by the RRI teams is specifically designed to validate concepts and insights derived from the computational biomedical research and to generate data used to inform mathematical models.

RRI's data analytics team includes highly specialized research design statisticians and epidemiologists, who can further our understanding of patient and population outcomes. The team has mastered a broad range of statistical methods, including descriptive analysis, longitudinal multidimensional models, predictive analytics, machine learning, and deep-learning neural networks. While the team's research portfolio involves a wide range of chronic kidney disease research initiatives, its primary focus is on improving kidney care through quantitative analysis. For several years, the team has been integral in the analysis of Crit-Line® data. Insights gleaned from the team’s work resulted in novel, groundbreaking research into the dynamics of intradialytic arterial and venous oxygen saturation, fluid overload, inflammation, sodium, blood pressure, and lipids.

Latest Research

New England Journal of Medicine
June 12, 2020

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Dr. Frank Maddux, Dr. Robert Kossman
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New England Journal of Medicine
June 12, 2020

Lorem ipsum dolor sit amet, nostrud consectetur adipiscing

Dr. Frank Maddux, Dr. Robert Kossman
Lorem ipsum dolor sit amet, consectetur adipiscing elit. In consectetur aliquam erat eu eleifend. Mauris nec nisl vel neque fermentum blandit eget enim. Nulla sodales placerat neque, vel bibendum turpis congue maximus.
The Journal of the American Medical Association
June 12, 2020

Lorem ipsum dolor sit amet, nostrud consectetur adipiscing

Dr. Frank Maddux, Dr. Robert Kossman
Lorem ipsum dolor sit amet, consectetur adipiscing elit. In consectetur aliquam erat eu eleifend. Mauris nec nisl vel neque fermentum blandit eget enim. Nulla sodales placerat neque, vel bibendum turpis congue maximus. Phasellus lobortis luctus lectus, sed varius ex pulvinar sed. Suspend isse sit amet mollis mauris.
Content Type
June 12, 2020

Lorem ipsum dolor sit amet, nostrud consectetur adipiscing

Dr. Frank Maddux, Dr. Robert Kossman
Lorem ipsum dolor sit amet, consectetur adipiscing elit. In consectetur aliquam erat eu eleifend. Mauris nec nisl vel neque fermentum blandit eget enim.

Our Research Lab

The RRI laboratory is at the center of our clinical trials and advanced data analytics. The lab employs sophisticated tools and methodologies to dig deeper, looking at questions and factors critical to the development of cutting-edge technologies, new medical devices, and innovative therapeutic methods.
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Patent Highlights

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Title of RRI Patent Goes Here

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